Overview   |   Publications

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Selected Publications

Zheng B, Liao Z, Locascio JJ, Lesniak KA, Roderick SS, Watt ML, Eklund AC, Zhang-James Y, Kim PD, Hauser MA, Grünblatt E, Moran LB, Mandel SA, Riederer P, Miller RM, Federoff HJ, Wüllner U, Papapetropoulos S, Youdim MB, Cantuti-Castelvetri I, Young AB, Vance JM, Davis RL, Hedreen JC, Adler CH, Beach TG, Graeber MB, Middleton FA, Rochet JC, Scherzer CR; Global PD Gene Expression (GPEX) Consortium. PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease. Sciend Translational Medicine, 2010 Oct 6;2(52):52ra73. PubMed | Reprint

Lipinski MM, Zheng B, Lu T, Yan Z, Py BF, Ng A, Xavier RJ, Li C, Yankner BA, Scherzer CR, Yuan J. Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer’s disease. Proceedings of the National Academy of Sciences U.S.A, 107(32): 14164-9, 2010 PubMed

Khurana V, Elson-Schwab I, Fulga TA, Sharp KA, Loewen CA, Mulkearns E, Tyynelä J, Scherzer CR, Feany MB. Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo. PLoS Genet. 2010 Jul 15;6(7):e1001026. PubMed

Kim J, Amante D, Moody JP, Edgerly CK, Bordiuk OL, Smith K, Matson S, Matson W, Scherzer CR; Rosas D, Hersch S, Ferrante, RJ. Reduced creatine kinase as a central and peripheral biomarker in Huntington's disease, Biochemica et Biophysica Acta – Molecular Basis of Disease, 1802(7-8): 673-81, 2010, PubMed.

Scherzer CR, Grass JA, Liao Z, Zheng B, Pepivani I, Eklund AC, Ney PA, Ng J, McGoldrick M, Moellenhauer B, Bresnick EH, MG Schlossmacher, Identification of the transcription factor directly regulating Parkinson’s disease-linked α-synuclein expression, Proceedings of the National Academy of Sciences U.S.A,105, 10907-10912, 2008. PubMed

Scherzer CR, Eklund AC, Morse LJ, Fefer D, Locascio JJ, Schwarzschild MA, Schlossmacher MG, Hauser MA, Vance J, Sudarsky LR, Standaert DG, Growdon JH, Jensen RV, SR Gullans, Molecular markers of early Parkinson’s disease based on gene expression in blood, Proceedings of the National Academy of Sciences U. PubMed

Xu P-T, Li Y-J, Qin X-J, Scherzer CR, Xu H, Schmechel DE, Christine M. Hulette CM, Ervin J, Gullans SR, Haines J4, Pericak-Vance MA and Gilbert JR, Differences in Apolipoprotein E3/3 and E4/4 Allele-Specific Gene Expression in Hippocampus in Alzheimer Disease, Neurobiology of Disease, 2005. PubMed

Hauser MA, Li Y-J, Xu H, Noureddine M, Shao S, Gullans SR, Scherzer CR, Jensen RV, McLaurin A, Scott B. et al. Expression profiling of substantia nigra in Parkinson disease, progressive supranuclear palsy, and frontotemporal dementia with parkinsonism, Archives of Neurology, 62,917-21, 2005. PubMed

Scherzer CR, Otte K, Gearing M, Heilman C, Gutekunst C-A, Fang G, Levey AI, and Lah J, Loss of ApoE receptor LR11 (alias SORL1) in Alzheimer’s disease, Archives of Neurology, 61, 1200-5, 2004. Selected for cover, reviewed in Archives of Neurology, 2004, 61, 1178-80; and perspective in Science, 315, 314, 2007. PubMed

Li Y-J, Oliveira AS, Xu P, Martin ER, Stenger JE, Scott WK, Hauser MA, Scherzer CR, Small GW, Martha A. Nance MA, Watts RL, Hubble JP, Koller WC, Pahwa R, Stern MB, Hiner BC, Jankovic J, Goetz CG, Mastaglia F, Middleton LT, Roses AD, Saunders AM, Schmechel DE, Katherine A. Welsh-Bohmer KA, Hulette C, Gullans SR, Haines JL, Gilbert JR, Vance JM, and Pericak-Vance MA, Glutathione S-Transferase Omega 1 modifies age-at-onset of Alzheimer Disease and Parkinson Disease, Human Molecular Genetics, 12, 3259-67, 2003. PubMed

Scherzer CR, Jensen RV, Gullans SR, Feany MB, Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson’s disease, Human Molecular Genetics. 12: 2457-66, 2003. PubMed

Reviews

Scherzer CR, Chipping away at biomarkers for neurodegenerative diseases, Neurobiology of Disease, in preparation.

Hennecke G and CR Scherzer, RNA biomarkers of PD: Developing tools for novel therapies, Biomarkers in Medicine, 2, 41-53, 2008

Growdon JH, Irizarry MC, and CR Scherzer, Biomarkers for Alzheimer’s and Parkinson’s disease. In Fisher A, Memo M, Stocchi F, Israel Hanin I (ed.), Advances in Alzheimer's and Parkinson's Disease, Springer US, 57:169-174, 2007

Scherzer CR, Atypical features of typical parkinsonism in Guadeloupe, Neurology Journal Watch, July 24, 2007

Scherzer CR, Gullans SR. and Jensen RV, Simplifying complex neurodegenerative diseases by gene chip analysis. In Freese A, Leone P, Janson C (ed.), Principles of Molecular Neurosurgery. Karger, Basel, 18,1-12, 2005

Scherzer CR and Feany MB, Yeast genetics targets lipids in Parkinson’s disease, Trends in Genetics, 20, 273-7, 2004. PubMed